KMID : 0370219960400050487
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Yakhak Hoeji 1996 Volume.40 No. 5 p.487 ~ p.490
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Synthesis of Phenolbetaine Derivatives and Their Anti-cancer Activity: Chemical Transformation of C-ring of Protoberberine
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¿ì¼ºÁÖ/Woo SJ
¹Ú¿¹Áø/Ȳ¼øÈ£/È«À¯È/À̸¶¼¼/±èµ¿Çö/±èÀÎÁ¾/±è½Å±Ô/Park YJ/Hwang SH/Hong YH/Lee MS/Kim DH/Kim IJ/Kim SK
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Abstract
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The 13-hydroxyberbine(1), derived from berberinephenolbetaine, has been derivatized to furnish a variety of compounds such as 13-oxoberbine(2), 13-thioberbine(3), 13-chloroberbine(4), 13-(2-methylaziridine)berbine(5) and 13-carbolactoneberbine(6). Antitumor activity of these compounds was tested.
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